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Why we might not get a coronavirus vaccine
Politicians have become more cautious about immunisation prospects. They are right to be

An article by Ian Sample Science editor of the Guardian

A chief concern is that coronaviruses do not tend to trigger long-lasting immunity. About a quarter of common colds are caused by human coronaviruses, but the immune response fades so rapidly that people can become reinfected the next year.

Researchers at Oxford University recently analysed blood from recovered Covid-19 patients and found that levels of IgG antibodies – those responsible for longer-lasting immunity – rose steeply in the first month of infection but then began to fall again.

   

https://www.theguardian.com/world/2020/may/22/why-we-might-not-get-a-coronavirus-vaccine

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He experienced a severe reaction to Moderna’s Covid-19 vaccine candidate. He’s still a believerTwelve hours after receiving his second dose, he developed a fever of more than 103 degrees, sought medical attention, and, after being released from an urgent care facility, fainted in his home. He recovered within a day.

“I understand that sharing the story, it’s going to be frightening to some people,” he said. “I hope that it doesn’t fuel any sort of general antagonism towards vaccines in general or towards even this vaccine.”

But he decided to speak now because he hopes his story counterbalances the desperation that some people feel to push a vaccine to market regardless of the consequences. Haydon points out that the whole purpose of the study he was in, known as a Phase 1 clinical trial, is to find the right dose of the vaccine going forward. That means to find a dose that causes the body to produce antibodies, but does not result in too many side effects.

“As we rush to get a vaccine developed as quickly as possible, the reality of vaccine development is that it can only be rushed so much and the trial still needs to take place,” Haydon said. “They have to move at the speed they move at. And stories like what happened to me, they matter because they shape the approval process.”

https://www.statnews.com/2020/05/26/moderna-vaccine-candidate-trial-participant-severe-reaction/

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Vaccines typically require years of research and testing before reaching the clinic, but scientists are racing to produce a safe and effective vaccine by next year. Work began in January with the deciphering of the SARS-CoV-2 genome. The first vaccine safety trials in humans started in March, but the road ahead remains uncertain. Some trials will fail, and others may end without a clear result. But a few may succeed in stimulating the immune system to produce effective antibodies against the virus. Here is the status of all the vaccines that have reached trials in humans, along with a selection of promising vaccines still being tested in cells or animals. –NY Times

https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html

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This vaccine tag search is very good for overview of all interim vaccine trials as they come through.

https://www.sciencemediacentre.org/tag/vaccines/